Aim: To perform the assay of Dapsone.
Molecular formula: C12H12N2O2S
Mol. Wt.: 248.3
Dapsone contains not less than 99.0% and not more than 101.0% of C12H12N2O2S calculated on the dried basis.
Dose: 100 mg daily.
Description: A white or creamy-white, crystalline powder.
- Dissolve 0.3 gm in a mixture of 20 ml of water and 20 ml of 2 M hydrochloric acid, add 3 gm of potassium bromide.
- Cool the solution to about 15°C and determine by nitrite titration.
- Carry out a blank titration.
Factor: 1 ml of 0.1 M sodium nitrite is equivalent to 0.01242 gm of C12H12N2O2S.
Storage: Store protected from light.
Uses: It is used as antileprotic drug.