Medicinal Chemistry

AIM: TO SYNTHESISE PHENYTOIN FROM BENZIL AND UREA. REQUIREMENTS:  Chemicals: Benzil, Urea, Sodium hydroxide, Ethanol, Concentrated hydrochloric acid. Apparatus: Round bottom flask (100ml), Reflux condenser, Crystallizing dish (500ml), Heating mantle, Stirrer, Beaker (400ml), Filtering flask with Büchner funnel, Graduated cylinders (100ml and 50ml), Petri dish etc. BACKGROUND: Principle: Base catalysed reaction is used between benzyl […]

Aim: To prepare 6-Hydroxy nicotinic acid from Coumalic acid. Requirements: Sulphuric acid, coumalic acid, methanol, sodium carbonate, hydrochloric acid, sodium hydroxide. Theory: Methyl coumalate is formed from coumalic acid in the presence of methanol. 6-hydroxy nicotinic acid is formed by reaction between methyl coumalate and ammonia. Reaction Involved: Procedure: 1. Preparation of Methyl coumalate: Place

Aim: To prepare and submit Hexamine from urea. Requirements: Porcelain dish, formaldehyde, ammonium hydroxide solution, ethanol,  Theory: Hexamethylenetetramine or methanamine or urotropine is a heterocyclic organic compound with the formula (CH₂)6N4. This white crystalline compound is highly soluble in water and polar organic solvents. Reaction involved: Procedure: Add 7.0 g of 20% ammonium hydroxide solution

AIM: TO PREPARE AND SUBMIT CHLOROBUTANOL FROM ACETONE. Requirements: Acetone, chloroform, potassium hydroxide, round bottom flask, Glass rod and Beaker. Theory: Chloroform (trichloro-2-methyl-2-propanol) is synthesised by nucleophilic addition of chloroform and acetone. The reaction is base driven by sodium or potassium hydroxide. Procedure: Mix dry acetone (5g) and chloroform (10g) with continued stirring & cool

Aim: To determine physicochemical and toxicity properties using free online services. Theory:     Bringing a pharmaceutical drug to the market is a long term process that costs sixty-five thousand crores of Indian rupees. One promising approach for improving the efficiency and productivity of early discovery in the pharmaceutical industry and academia is Virtual screenings

Steroidal Nomenclature and Structure of Steroids, Stereochemistry Steroidal Chemistry is an important part of syllabi in Medicinal Chemistry II, B Pharmacy 5th semester. In This article you came to know about some important basic concepts of Steroidal Nomenclature. Here we will discuss some common structure and Stereo Chemistry of some important steroids. Gonane, Estrane, Pregnane,