BPharm 6th Sem Notes

 Aim: To determine partition coefficient of Naphthalene using shake flask method. Requirements: Laboratory stand, separatory funnel (500 ml), calibrated cylinder (50 ml, 500 ml), funnel, beaker (500 ml, 100 ml), vial, mini-vial, automatic pipette, distilled water. Theory: The octanol-water partition coefficient, Kow, describes equilibrium partitioning of a chemical between octanol and water phases. It is […]

Aim: To perform the assay of Dapsone. Molecular formula: C12H12N2O2S Mol. Wt.: 248.3 Dapsone contains not less than 99.0% and not more than 101.0% of C12H12N2O2S calculated on the dried basis. Category: Antileprotic. Dose: 100 mg daily. Description: A white or creamy-white, crystalline powder. Assay: Dissolve 0.3 gm in a mixture of 20 ml of

Aim: To prepare and submit 7-hydroxy-4-methyl Coumarin from Resorcinol by green technique (Pechmann Condensation). REQUIREMENT: Ethyl acetoacetate, resorcinol, pipette, measuring cylinder. THEORY: Resorcinol reacts with ethyl acetoacetate in the presence of concentrated sulphuric acid to form 7-hydroxy-4-methyl Coumarin. PROCEDURE: Dissolve 1.1g resorcinol in 1.35g of ethyl acetoacetate in a 50ml dry round bottom flask. Add 1.5g K10-montmorilonite clay to the

AIM: TO SYNTHESISE PHENYTOIN FROM BENZIL AND UREA. REQUIREMENTS:  Chemicals: Benzil, Urea, Sodium hydroxide, Ethanol, Concentrated hydrochloric acid. Apparatus: Round bottom flask (100ml), Reflux condenser, Crystallizing dish (500ml), Heating mantle, Stirrer, Beaker (400ml), Filtering flask with Büchner funnel, Graduated cylinders (100ml and 50ml), Petri dish etc. BACKGROUND: Principle: Base catalysed reaction is used between benzyl

Aim: To prepare 6-Hydroxy nicotinic acid from Coumalic acid. Requirements: Sulphuric acid, coumalic acid, methanol, sodium carbonate, hydrochloric acid, sodium hydroxide. Theory: Methyl coumalate is formed from coumalic acid in the presence of methanol. 6-hydroxy nicotinic acid is formed by reaction between methyl coumalate and ammonia. Reaction Involved: Procedure: 1. Preparation of Methyl coumalate: Place

Aim: To prepare and submit Hexamine from urea. Requirements: Porcelain dish, formaldehyde, ammonium hydroxide solution, ethanol,  Theory: Hexamethylenetetramine or methanamine or urotropine is a heterocyclic organic compound with the formula (CH₂)6N4. This white crystalline compound is highly soluble in water and polar organic solvents. Reaction involved: Procedure: Add 7.0 g of 20% ammonium hydroxide solution

AIM: TO PREPARE AND SUBMIT CHLOROBUTANOL FROM ACETONE. Requirements: Acetone, chloroform, potassium hydroxide, round bottom flask, Glass rod and Beaker. Theory: Chloroform (trichloro-2-methyl-2-propanol) is synthesised by nucleophilic addition of chloroform and acetone. The reaction is base driven by sodium or potassium hydroxide. Procedure: Mix dry acetone (5g) and chloroform (10g) with continued stirring & cool